Chestnut blight can be controlled using viruses that infect the blight-causing fungus. The infection reduces the ability of the fungus to cause disease, a condition that is called hypovirulence.

Another method to control chestnut blight is selective breeding of the American chestnut for resistance. Resistant hybrids of American and Chinese chestnut are also being developed.

American chestnuts can be grown outside of their historical range. This helps to conserve the species.